Discuss: The bigger picture (3.5 and beyond)

What are some bigger ticket items that we’d like to see happen in core? What really needs to be made better/easier/prettier but takes some effort to achieve?

Again, one item per comment, and then discuss each (or add your +1) in replies to that comment. Talk about what you think effort might be, how it might be broken out into subtasks, and whether it’s something you see as a feature/enhancement for 3.5 or a longer-term project for another future release.