Discuss: The bigger picture (3.5 and beyond)

What are some bigger ticket items that we’d like to see happen in coreCore Core is the set of software required to run WordPress. The Core Development Team builds WordPress.? What really needs to be made better/easier/prettier but takes some effort to achieve?

Again, one item per comment, and then discuss each (or add your +1) in replies to that comment. Talk about what you think effort might be, how it might be broken out into subtasks, and whether it’s something you see as a feature/enhancement for 3.5 or a longer-term project for another future release.